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The expression of reticulon-1A (RTN1A), an ER-associated protein, was found to be elevated in diabetic kidneys of both humans and mice, and the expression of RTN1A is associated with the progression of DKD (83)

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Abstract Kidney injuries may trigger renal fibrosis and lead to chronic kidney disease (CKD), but effective therapeutic strategies are still limited

The human pilot study on BPC-157 found that it was tolerated well in doses of up to 20mg when given intravenously, and no adverse side effects were seen [14]

This is likely because sermorelin cannot result in an excessively high rise in serum GH or IGF-1 concentrations, in contrast to GH therapy [29]