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The efficacy and safety of the combination therapy with GLP-1 receptor agonists and SGLT-2 inhibitors in type 2 diabetes mellitus: a systematic review and meta-analysis

On this basis he differentiated diabetes into type 1 (insulin sensitive) and type 2 (insulin insensitive)

10.1016/j.molmet.2015.07.008 [DOI] [PMC free article] [PubMed] [Google Scholar] D'Agostino, G

They have not been reviewed by the FDA and are not intended to diagnose, treat, cure, or prevent any disease

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For instance, a large network meta-analysis showed that SGLT-2 inhibitors reduced hospitalization for HF and renal composite outcome more than GLP-1RA [15], and that in patients with cardiovascular disease, SGLT-2 inhibitors show significant reduction in both heart failure (HF) hospitalizations and mortality for patients with HF and reduced ejection fraction [16]