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Li LC, Liang LM, Ji HY, Zhang C, Wang M, Liu HS

Several studies have optimized urea-containing compounds such as SBI-797812 and 1-(2-phenyl-1,3-benzoxazol-6-yl)-3-(pyridin-4-methyl)urea (DS68702229) as potent NAMPT activators, which have been shown to increase NAD + levels in vitro and in vivo, with potential applications in treating metabolic disorders, cardiovascular diseases, and neurodegeneration preclinically 221,222

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Hormonal regulation of metabolism: the role of enteroendocrine cells and incretins Metabolic regulation is tightly controlled by a complex network of hormones, many of which are secreted by enteroendocrine cells (EECs) , specialized sensory cells that make up about 1% of the gut epithelium

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