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At the end of the experiment, the rats were euthanized, and the lung tissues were collected for histopathological, immunohistochemical, biochemical, and genetic analysis

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17 Notably, these clinical trials were not designed to study ocular outcomes, and DR was reported as an adverse event, not a primary outcome

Peer review Peer review information Nature Communications thanks Kathrin Ulrich and John Mieyal for their contribution to the peer review of this work

Changes in CaMKII and MEK1/2 activity were closely related to cytoplasmic Ca 2+ concentration

There was a significant increase in expression of neuronal marker such as Nestin, Musashi, CD133, and GFAP (Nr et al., 2013)