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B., Mezey, E., Button, D

IGF-1 LR3 and Glucose Metabolism Research In differentiated 3T3-L1 adipocytes, IGF-1 LR3 was used to investigate IGFBP-independent IGF-1R-mediated glucose uptake pathways, with research confirming that its effects on glucose transport are mediated directly through the IGF-1 receptor rather than through IGFBP modulation providing a clean experimental tool for dissecting receptor-specific metabolic signalling

Front Aging Neurosci 10:350

Neurobiology of opioid dependence in creating addiction vulnerability

Free radicals may contribute to oxidative skeletal muscle fatigue

In accordance with the glutathione activator hypothesis, only positively charged amino acids replace Lys105 in enzymatically active glutaredoxins, whereas in inactive isoforms and other members of the thioredoxin superfamily the activator candidate is often separated from the catalytic cysteine residue in the primary sequence or is replaced by uncharged residues 3,11,12 (Fig