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Hepatitis/Elevated liver enzymes/Jaundice Diabetic retinopathy problems: Changes in vision in those with Type 2 diabetes, particularly vision problems may worsen in those with a history of diabetic retinopathy Severe gastrointestinal disease - may cause gastrointestinal disease

The cardioprotective mechanisms of GLP-1 RAs are thought to involve a combination of anti-inflammatory and antioxidant actions, reduced secretion of atherogenic lipoproteins, improved vascular endothelial function, and blood pressure regulation 32,33

BOTTOM LINE: Those at greatest risk of vitamin B12 deficiency are vegans and vegetarians, who get little to no B12 from the diet

The Risk of Gout Among Patients With Sleep Apnea: A Matched Cohort Study

doi: 10.1016/j.jasms.2006.06.012

Important Considerations: Vitamin B12 shots are generally safe, but there may be mild side effects at the injection site