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In T2D patients, BCAAs are associated with cardiovascular complications and mortality risk ( 4.4 Metabolic dysfunction-associated steatotic liver disease: pathological mechanisms in non-cirrhotic disease 4.4.1 Bidirectional relationship between BCAAs and MASLD in non-cirrhotic disease The pathological mechanisms described in this section pertain specifically to early and non-cirrhotic MASLD/MASH, a stage at which fasting circulating BCAA concentrations are characteristically elevated as a consequence of impaired catabolic disposal