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As shown in the Number of trials and Number of patients columns in the table, antidepressants were overall poorly investigated in small RCTs and with low to moderate SMDs between drug and placebo (SMD (95% CI)

Additionally, many claims regarding BPC-157s benefits stem from preclinical studies that do not provide sufficient evidence for human applications

Results suggest that polyphenols enhance metabolism through anti-inflammatory and lipid-modulating mechanisms, potentially via nuclear hormone receptor activation [79]