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It can be concluded that the dopaminergic deficit is efficiently compensated for a long period of time, at least 10 years or longer, during the normal or near-normal motor activity (silent/prodromal motor period) before clinical symptoms are sufficient for diagnosis (manifested period) [41]

If you are on all three medications, spacing them throughout the day becomes even more important

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Serve with naan, an Indian flatbread, or with rice, with yogurt-based raita on the side.

That tends to lend more credence to what the pathophysiology shows, which is that tachyphylaxis can happen after a certain time point, she said