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Short-term safety is well-established at doses up to 1200mg per day, but chronic daily supplementation may downregulate endogenous glutathione synthesis through negative feedback on gamma-glutamylcysteine synthetase

J Biol Chem 278:2224322249

Emerging therapies: novel mechanistic targets arising from pathobiology In recent years, significant advancements have been achieved in the treatment of IBD, particularly with the introduction of biologic agents, which have substantially improved disease management

PMID: 32917265 Brain Sci AngIV-Analog Dihexa Rescues Cognitive Impairment and Recovers Memory in the APP/PS1 Mouse via the PI3K/AKT Signaling Pathway