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10.1016/j.jbc.2021.100514 44 DuffyA.HorrocksJ.DoucetteS.Keown-StonemanC.McCloskeyS.GrofP

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Metabolic and Molecular Effects of Exercise on Oestrogen in Skeletal Muscle Oestrogens are steroid hormones, primarily produced in the ovaries from testosterone via an aromatase enzyme, of which women have four times the amount compared with men, until the menopause (Hansen and Kjaer, 2006)- an action mediated by the estrogen receptors, located within skeletal muscle tissue that function as transcription factors (Hansen and Kjaer, 2018)

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Post-inflammatory hyperpigmentation PIH is the dark mark that lingers after a spot, injury, or inflammatory skin condition like eczema