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Phase 1 Trials In a first-in-human, randomized, placebo-controlled, single ascending dose, phase 1 trial in healthy participants, retatrutide demonstrated a favourable safety profile (similar to other incretin-based therapies) and early signs of efficacy with dose-dependent WL [42]

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Median CAP indices were 311 and 284 ( p = 0.04) and the median LSM scores were 7.8 and 5.8 ( p = 0.02) in patients treated with conventional and triple therapy, respectively