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Lipid-laden adipocytes produce increased levels of cytokines such as Interleukin 6 (IL-6), IL-, TNF-, monocyte chemoattractant protein-1 (MCP-1), and IL-8 [10, 56, 57] which can inhibit preadipocyte differentiation [21, 45]

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RT-qPCR of mouse dorsal skin after treatment further confirmed the upregulation of IGF-1, VEGF, Elastin, and HAS2, while the downregulation of TNF- and IL-1

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