Yen, Head of the Laboratory of Hormonal Regulation at Duke-NUS' Cardiovascular & Metabolic Disorders Programme, and senior author of the study, said, "The potential for using vitamin B12 and folate, which have high safety profiles and are designated as dietary supplements by the US Food and Drug Administration, as first-line therapies for the prevention and treatment of NASH could result in tremendous cost savings and reduce the health burden from NASH in both developed and developing countries." Currently, the only treatment for patients with end-stage liver disease is to receive a transplant
An overdose of vitamin B12 through diet is hardly possible and also not known, since the required transport protein IF (intrinsic factor) and absorption via the intestinal mucosa are two major barriers
This is a key variable to consider in experimental design
This isn't about one being better than the other
DNA was not isolated from the first two samples collected in the LD/LD-V group, and the first sample collected in each of the other respective groups, due to the use of saline to flush the cecum (after weighing) during early collection (therefore, n = 25 cecal samples)
Archives of Medical Science : AMS 8(5):924930
