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Microdose protocols (lower starting doses with gradual titration) may allow the gastrointestinal system to adapt with fewer acute side effects, though clinical data on this strategy is still emerging
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If future research continues to support the heart and kidney benefits seen in current trials, GLP-1 medicines could become part of a broader strategy aimed not only at managing disease but potentially delaying some of its most serious consequences
As mentioned earlier, GLP-1 RAs function similarly to statins by inhibiting HMG-CoA reductase, suggesting that GLP-1 RAs can be prescribed as not only an antidiabetic medication but also as a cholesterol-lowering medication that can reduce the prevalence of CVD [64,65,70-73]
Specifically, patients were randomized in an open-label fashion to receive either: (i) PIO 30 mg/day for 2 weeks followed by PIO 45 mg/day for 50 weeks ( n = 10) or (ii) EXE 5 g twice daily and PIO 30 mg/day for 2 weeks followed by EXE 10 g twice daily and PIO 45 mg/day for 50 weeks ( n = 11)
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