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Epileptic seizures lead to cognitive impairment in patients with respect to execution ability, language ability, attention, judgment, and mental disorders, thereby severely affecting the employment ability and social communication level of epilepsy patients and reducing the quality of life (Witt and Helmstaedter, 2015

Regarding glutamine metabolism, CB-839, a selective GLS1 inhibitor, has not demonstrated significant side effects in preclinical studies and is currently undergoing multiple clinical trials in lung cancer (NCT04250545) and pancreatic ductal adenocarcinoma (NCT03965845)

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