2245-A PROJECTION OF THE CLINICAL BURDEN OF NAFLD IN US ADULTS FROM 2020-2050: A MODELING STUDY Phuc Le 1 , Moosa Tatar 1 , Srinivasan Dasarathy 2 , Naim Alkhouri 3 , William Herman 4 , Abhishek Deshpande 1 , Glen Taksler 1 , Wen Ye 5 and Michael Rothberg 1 , (1)Cleveland Clinic, (2)Cleveland Clinic Foundation, (3)Arizona Liver Health, Phoenix, AZ, (4)University of Michigan Medical School, (5)University of Michigan Background: Following the alarming rise in prevalence of obesity and diabetes, nonalcoholic fatty liver disease (NAFLD) is projected to become the leading indication for liver transplant (LT) in the United States in the next decade
Disruption of the Mouse Mdr1a P-Glycoprotein Gene Leads to a Deficiency in the Blood-Brain Barrier and to Increased Sensitivity to Drugs
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