Int J Endocrinol Metab
385,387 PF1801 displays its anti-inflammatory effects by lowering levels of inflammatory mediators such as TNF, IL-6, and HMGB1, and enhances the cells antioxidant capability by upregulating molecules like Nfe2l2, Hmox1, Gclm, and Nqo1, which further improves cellular defense against oxidative stress and protects them from further damage
In HF, metabolic derangements in cardiac substratesincluding fatty acids, glucose, ketones, lactate, and amino acidscontribute to myocardial metabolic remodelling and ultimately lead to structural and functional impairments [150]
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Greater proportions of patients treated with WEGOVY achieved 5%, 10%, and 15% weight loss than those treated with placebo as shown in Table 9