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Hence, an active glucose metabolism partly amplifies the substrate pool for lipid peroxidation ( 3.4.3 Energy status and oxidative stress balance In OA lesions, synovial inflammation and cartilage degeneration reduce local nutrient availability and oxygen levels, compelling cells to adapt their energy-generating modes ( In OA, cells and tissues undergo extensive metabolic reprogramming in response to chronic inflammation and mechanical stress

On the contrary, a study conducted by Jacobsen et al

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Tamping down inflammation has the opposite effect

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The traces of three consecutive measurements were averaged and fitted by single exponential or double exponential regression using the Pro-Data SX software (Applied Photophysics)