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Abbreviations 2,3-BPG: 2,3-Bisphosphoglyceric acid AA : Amino acid ANLS: Astrocyte-neuron lactate shuttle ATP: Adenosine triphosphate AUC: Area under the curve BBB: Bloodbrain barrier BCAA: Branched chain amino acid CCI: Controlled cortical impact CMD: Cerebral microdialysis CNS: Central nervous system coA: Coenzyme A cPLA2 : Cytosolic phospholipases A2 CSF : Cerebrospinal fluid CT : Computed tomography ETC: Electron transport chain FOXP3: Forkhead box P3 GCS: Glasgow coma scale GFAP: Glial fibrillary acidic protein GLUT: Glucose transporters GOS(E): Glasgow outcome scale (extended) GSH: Glutathione peroxidase H-NMR: Proton nuclear magnetic resonance HIF-1: Hypoxia-inducible factor-1alpha ICP: Intracranial pressure ICU: Intensive care unit IL: Interleukin iNOS: Inducible nitric oxide synthase LPC: Lysophosphatidylcholine LPR: Lactate/Pyruvate ratio LPS: Lipopolysaccharide MS: Mass spectrometry NAA: N-acetylaspartate NAD(H): Nicotinamide adenine dinucleotide NADP(H): Nicotinamide adenine dinucleotide phosphate NF-B: Nuclear factor kappa B NOX: NADPH oxidase NRF2: Nuclear factor erythroid 2-related factor 2 O-LPC: Ether lysophosphatidylcholine PbtO2: Partial pressure of brain tissue oxygen PEP: Phosphatidylethanolamines PET: Positron emission tomography PGC1a: Peroxisome proliferatoractivated receptor gamma coactivator-1 alpha ROS: Reactive oxygen species S100B: S100 calcium-binding protein B Sirt1: NAD-dependent deacetylase sirtuin-1 SM: Sphingomyelin TBI: Traumatic brain injury TCA: Citric acid cycle, krebs cycle TG: Triglyceride TIL: Therapeutic intensity level UCH-L1: Ubiquitin C-terminal hydrolase-L1 References Centers for Disease Control and Prevention

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NAD+ Injection (Aqueous) NAD+ Injection (Aqueous) 5 mL NAD+ Injection (Aqueous) 10 mL Product Overview NAD+ Injection is a compounded prescription formulation of nicotinamide adenine dinucleotide (NAD+), a coenzyme found in all living cells and crucial for fundamental biological processes

Why NAD+ Matters for Skin Health NAD+ (Nicotinamide Adenine Dinucleotide) is an essential coenzyme present in every living cell

Among both the explants, leaf exhibited superior callus induction compared to hypocotyl explants on the optimized medium containing BAP (1.5 mg L -1 ) and NAA (1 mg L -1 )

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