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Today, were going there to unpack a topic with a lot of chatter around it: the skyrocketing popularity of GLP-1 drugs, a class of medications gaining attention for their use in treating obesity and diabetes

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114 g Fmoc-Gly-2-CTC Resin (42 mmol) with a degree of substitution of 0.368 mmol/g was weighed and swelled for 30 min with DMF, followed by sequentially coupling according to the amino acid sequence of Semaglutide with 2-5 equivalents of amino acid feeds and condensing with DIC+A or B+A+C, until the resin was detected to be transparent with ninhydrin, wherein A was HOBt or HOAt

So 0.1mL = 10 units

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However, those studies used a lower dose of semaglutide (40 vs