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Beyond oxidative damage, alpha-synuclein ( -syn) aggregation is a central pathological hallmark of PD, as it is the major component of Lewy bodiesabnormal deposits of proteins found in the brains of patients with PD (Paulkas et al., 2024)

The best way to reduce the risk is to lose weight slowly, eat enough protein, stay hydrated, and do strength training

Smad3 deficiency protects mice from obesity-induced podocyte injury that precedes insulin resistance

43% of people on a GLP-1 reach the 1.2 g/kg protein target 4665% stop within 12 months cost and side effects lead ~ of lost weight tends to return within a year without a plan On muscle loss the honest version: About 40% of the weight lost in the STEP-1 trial was lean mass (Neeland 2024)

Wheeler recommends these medications to his patients