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In ovarian stromal cells of PCOS patients, LH enhances CYP17A1 phosphorylation via the cAMP/PKA pathway, upregulating 17-hydroxylase and 17,20-lyase activities and leading to excessive production of androstenedione and testosterone ( Moreover, excessive LHCGR activation may trigger premature luteinization of granulosa cells through ERK1/2-mediated phosphorylation, disrupting dominant follicle selection

PMC 6492459

[DOI] [PMC free article] [PubMed] [Google Scholar] 11.Zheng T.P., Liu Y.H., Yang L.X., Qin S.H., Liu H.B

Genomics 30 , 192204 (2007)

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