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Biological replicates (individual fish) are stated in the figure legends, and include (non-exhaustive): plasma TMT proteomics ( n = 5 adult versus n = 5 aged-adult male fish)

Tumour redox state, hypoxia, and acidosis imaging Tumour microenvironmental characteristics such as hypoxia, altered redox balance, and extracellular acidosis have emerged as central determinants of tumour aggressiveness, metastatic potential, and therapeutic resistance (181, 182)

Beerepoot, P., Nazari, R

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