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Collectively, this dual metabolic identity, preserving physiological specialization in citrate production while hijacking polyamine and citrate pathways for oncogenic rewiring, not only distinguishes PCa from other malignancies but also unveils targetable vulnerabilities for diagnostic and therapeutic innovation

doi: 10.1124/dmd.111.039149

Trials on stroke and traumatic brain injuries with competitive glutamate or glycine antagonists (i.e., selfotel, aptiganel, eliprodil, licostinel, and gavestinel) have failed (Ikonomidou and Turski, 2002)

For example, knockout of the WNT/-catenin target gene cyclin D1 impairs LTP and spatial memory in mice (Ge et al., 2020

If you have one or two copies of the ApoE4 mutation you have about a 500% to 1,200% increased risk for developing Alzheimers disease respectively compared to those who do not have the mutation

Beyer RE