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Exercise improves your body's sensitivity to its own hormones, including GLP-1

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Clinical efficacy : Large randomised controlled trials demonstrate that GLP-1 receptor agonists can reduce HbA1c by approximately 1.01.5% and produce weight loss of 515% of body weight, with the higher end of weight loss typically seen with higher-dose semaglutide (2.4mg/Wegovy) specifically for obesity treatment

The study provides a detailed mechanistic insight into the interplay between metabolic reprogramming, protein stability, and drug response in the context of obesity and cancer

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It is carcinogenic (cancer causing), immune suppressive, and can cause liver disease