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Macrophage-mediated inflammation in metabolic disease

The fluid shear stress sensor TRPM7 regulates tumor cell intravasation

P., & SCALE Obesity and Prediabetes NN8022-1839 Study Group (2015)

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While intermediate metabolites associated with TCA cycle (Tricarboxylic Acid Cycle) such as fumarate, succinate, and malate were not significantly different between the groups, we suggest a decrease in mitochondrial activity may result in lower ATP generation as reported in other inflammatory conditions (65, 66)