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Although costs of some have gone down recently, branded GLP-1s are typically $499/month and up, if you are paying out of pocket

Weight loss appears to be more rapid in the first 10-12 weeks, but it continues to decrease at a slower rate thereafter (64)

GLP-1 Receptor Agonists: Increased insulin secretion, decreased glucagon and glucose production, slowed gastric-emptying, appetite suppression all packaged together in a beautiful weight loss and blood sugar lowering solution

Summary: Ozempic does not directly cause sore throat as a recognised pharmacological side effect, though some patients report throat discomfort potentially linked to indirect mechanisms such as gastro-oesophageal reflux or nausea

In Phase 2 trials, retatrutide produced approximately 24% mean weight loss at 48 weeks at 12 mg, compared with about 22.5% for tirzepatide at 15 mg in the SURMOUNT-1 trial though direct head-to-head data is not yet available