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We treated the MOLP-8 myeloma cell line with increasing concentrations of the ERK5-CHAMP RNK06138 for 24 h and observed a dose-dependent decrease in ERK5 protein levels with a Dmax (maximum degradation) of 74% and DC 50 (half-maximal degradation concentration) of 111.7 nM

2008;10(3):547-557.[DOI] 27

Glutation to tripeptyd, ktry jest syntetyzowany z trzech aminokwasw: L-cysteiny, glutaminianu i glicyny

Studies have shown that 4-HNE and 4-HNE-modified proteins are closely associated with cartilage homeostasis by affecting the anabolic and catabolic processes of the chondrocytes

10.1097/00001756-200507130-00005 28 KvestadI.HysingM.ShresthaM.UlakM.Thorne-LymanA

The untreated wounds appeared light blue, indicating a sparse distribution of collagen protein in the granulation tissue (white rectangle)