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There is growing evidence that such crosstalk in cancer cells has important implications in the efficacy of novel therapeutics

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Free Rad Biol Med 40:92839 Hunot S, Vila M, Teismann P, Davis RJ, Hirsch EC, Przedborski S, Rakic P, Flavell RA (2004) JNK-mediated induction of cyclooxygenase 2 is required for neurodegeneration in a mouse model of Parkinsons disease

These adverse events lead some patients to discontinue therapy before achieving optimal clinical outcomes, reducing long-term treatment adherence

Kjems, L., Holst, J., Volund, A., Madsbad, S