Cosby, K
In vivo studies showed that perillyl alcohol effectively alleviated CFA-induced inflammation, with significant reductions in clinical parameters such as the arthritis index, complete erythema and swelling of the toes and ankles, and body weight in rats
This bioenergetic failure is the physiological root of post-exertional malaise (PEM), where even minor physical or cognitive exertion leads to a disproportionate and prolonged exacerbation of symptoms
Evidence snapshot: The strongest human evidence comes from a 2-year randomized controlled trial in 65 healthy older adults (Nass et al., 2008, Annals of Internal Medicine) showing sustained GH/IGF-1 increases and preserved fat-free mass, plus an earlier short-term human polysomnography study on sleep (Copinschi et al., 1997, Neuroendocrinology, PMID 9349662)
: Caution: For external use only
Music therapy for children with autism: Investigating social behaviour through music