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their deposition causes deleterious effects on neurodegenerative diseases, diabetes, arthritis, and cell damage through involving the NF-B, MAPKs, and Keap1-Nrf2-ARE etc

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Consequently, this leads to a reduction in the flux toward methionine-derived metabolites and redirects cysteine utilization toward glutathione, thereby enhancing plant protection

The pathway may present mutations in the tumor suppressor gene BAP1