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Initial studies reported that concentrations of AFB 1 which are likely to be achieved in the liver following ingestion of real-world concentrations of AFB 1 are bioactivated to AFBO primarily by CYP1A2, whereas much higher concentrations are catalyzed by CYP3A4 [30], [46], [79]

Image: Christoph Burgstedt/Science Photo Library/Getty Images/Getty Images About the Author Howard E

I also enjoyed this article because it gave me flashbacks to this article from the Onion about innovation with more blades on razors: A quick aside on the PPAR agonism story: The thiazolidinediones like Actos and Avandia treat diabetes with this mechanism of action

This suppression can lead to irregular or missed ovulation, increasing the risk of functional ovarian cysts

And it suppresses glucagon release, which helps regulate blood sugar after meals

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