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Hyslop PA, Zhang Z, Pearson DV, Phebus LA
Physiological Reviews, 82(1), 47-95
Regulatory and compounding status All four compounds share a broadly similar regulatory landscape in the United States as of 2026: None are FDA-approved as finished drug products for therapeutic use All are classified as WADA S2 prohibited substances year-round All four have 503A compounding status of Under Review, meaning the FDA Pharmacy Compounding Advisory Committee (PCAC) has nominated them for evaluation but final category assignments (Category 1 permitted for compounding
Slow oxidation during storage creates disulphide bridges between peptide chains that predispose the peptide to aggregation when water is added
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