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The least-square means estimands were generated for the three-way interaction for MC4R carrier status, pooled treatment (collapsed 5, 10 and 15 mg treatment groups versus placebo) and visit

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Contact your provider immediately if irritability becomes severe, escalates rather than settling, meaningfully disrupts daily functioning, or is accompanied by suicidal thoughts

It can introduce confounding variables that make your results meaningless

Joint pain, particularly in weight-bearing joints like knees and hips, commonly improves as weight decreases

If you experience new or severe back pain while taking semaglutide, the cause is more likely related to weight loss mechanics, pre-existing spinal conditions, or unrelated musculoskeletal strain rather than the medication