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In addition to targeting iron acquisition proteins, some efficacy has been achieved with vaccines targeting iron homeostasis in pathogens

Second, the execution core of ferroptosis involves the peroxidation of polyunsaturated fatty acid-containing phospholipids(PUFA-PLs) in membrane lipids, leading to the massive accumulation of cytotoxic lipid peroxidation derivatives such as specific lipid hydroperoxides and reactive aldehydes like 4-hydroxynonenal(4-HNE), ultimately causing irreversible damage to plasma membrane integrity (Guo et al., 2024)

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Slight up-regulation of egtA expression was seen after wild-type treatment with H 2 O 2 , which is in accordance with the results for ATCC26933 exposed to 3 mM H 2 O 2