We also tested a non-CRC model, the osteosarcoma U2OS cell line, which is wild-type for APC, KRAS and p53, and confirmed a similar 5FU-driven change in mitochondrial mass and morphology (Extended Data Fig
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Season two shifts Joe and the action to the west coast, though on the surface much is the same, even the tension-heavy set pieces, whether thats a jogger being chased and bludgeoned (or almost), or a suspicious police officer who sees through Joes well-honed charms, or that glass cage, lovingly reconstructed in a storage unit