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NPJ Syst Biol Appl

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Fitz, V., Graca, S., Mahalingaiah, S., Liu, J., Lai, L., Butt, A., Armour, M., Rao, V., Naidoo, D., Maunder, A., et al

Options include: Other GLP-1 receptor agonists (such as semaglutide or dulaglutide), though these share similar mechanisms and side effect profiles SGLT2 inhibitors (such as dapagliflozin or empagliflozin), which work through different mechanisms and have cardiovascular and renal benefits DPP-4 inhibitors (such as sitagliptin), which have a more modest effect on glycaemic control and weight Metformin (if not already prescribed), which remains the first-line treatment for type 2 diabetes according to NICE guidelines Insulin therapy (for patients requiring more intensive glycaemic control) For weight management specifically , alternatives to tirzepatide (Zepbound) include semaglutide 2.4 mg (Wegovy), which is approved by NICE for managing overweight and obesity, orlistat, or comprehensive lifestyle intervention programmes

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Microdosing for Appropriate Candidates Not everyone needs or tolerates a full therapeutic dose of tirzepatide