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Moreover, PBPK models can incorporate physiological, preclinical, and clinical data into the model to predict drug exposure during pregnancy [140,141]

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A simple screening questionnaire at each follow-up visit, such as the PHQ-9 for depression and the GAD-7 for anxiety, provides objective data that can detect changes before they become problematic

Ideal candidates are adults with a BMI of 30 or higher, or a BMI of 27 or higher with weight-related health conditions such as type 2 diabetes, hypertension, or high cholesterol, who have not achieved significant weight loss through diet and exercise alone

they optimize the metabolic environment to support long-term success