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10.1073/pnas.92.22.10339 Proc

J Mol Biol 436:

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Acute Symptom Relief Temporary rest from aggravating activities (high-impact or repetitive knee-bending) Ice application after activity to minimize pain and swelling Use of NSAIDs for short-term pain/inflammation relief, if needed Soft compressive knee sleeves or taping for additional support 2

These are customized medications that allow for flexible dosing and can be a more accessible option for many people

The obesity trial showed weight reductions of up to 14.7% at 36 weeks with the 45 mg dose, while the diabetes trial demonstrated HbA1c reductions of up to 2.1 percentage points and weight loss of up to 10.1 kg at 26 weeks