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NishimuraESHishikawaANakamichiRAkashioRChikumaSHashiguchiAet alDNA damage in proximal tubules triggers systemic metabolic dysfunction through epigenetically altered macrophages

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This copper-binding tripeptide activates TGF-beta/SMAD pathway signaling, stimulates collagen I and III synthesis, upregulates TIMP-1 and TIMP-2 to protect collagen from degradation, and modulates gene expression across approximately 4,000 human genes

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Furthermore, it may modulate growth factors that play essential roles in healing, offering a more robust recovery framework