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The Cochrane Collaboration Risk-of-Bias tool was used for quality assessment of the RCTs [18], including sequence generation, allocation concealment, blinding, incomplete outcome data, and selective outcome reporting

The absence of reports on SA in PWS highlights the lack of awareness to the topic

Retaining 3 body mass index (BMI) units during two years between births increases the risk of adverse maternal and infant outcomes

Emerging clinical evidence suggests that GLP-1-mediated insulin secretion regulation is impaired in conditions of obesity and insulin resistance [121]

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Peer review Peer review information Nature Reviews Endocrinology thanks Juan Pablo Frias, Baptist Gallwitz and the other, anonymous, reviewer(s) for their contribution to the peer review of this work