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This, in turn, allows fatty-acid producing gut bacteria to thrive at the expense of gut pathogens (Wu et al., 2020) and promotes a normal permeability of the gut-blood barrier (Ramalingam et al., 2010)

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Proteins were then precipitated by addition of 500 l methanol (pre-cooled at 80 C), 400 l LCMS-grade water, and 100 l chloroform, and the mixture was vortexed and centrifuged (10,000 g, 10 min, 4C) to afford a protein disc at the interface of CHCl3 and aqueous layers

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CagriSema showed better glycemic management and weight loss than either of its components as single agents