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Discussion The in vivo study demonstrated that lidocaine could be slowly released from the lidocaineepirubicinlipiodol emulsion and the randomized clinical trial showed that pain scores were significantly lower in patients who received intraarterial lidocaine injection by the W/O technique at T 0 , T 4 , T 8 , and T 24 after the procedure compared to patients who received an intraarterial bolus injection of lidocaine

Inflammatory cytokines and uremic toxins, including trimethylamine-N-oxide (TMAO), activate the NLRP3 inflammasome and NF-B pathways in VSMCs, upregulating osteogenic markers like Runx2 and BMP2 (65)

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