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Interestingly, in some cells of the ARC nucleus, it is also possible to find neuropeptide receptors (molecules with a role in the regulation of calorie intake) together with GIP-R, probably implicated in the regulation of food intake

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Patients with MCAS are divided into 5 clinical phenotypes or variants: primary form resulting from activation of clonal MC (predominantly mastocytosis), secondary MCAS involving nonclonal MCs activated by underlying conditions such as IgE-mediated allergies and other diseases, combined MCAS (activation of clonal and nonclonal MC), hereditary -tryptasemia (HT) associated with MCAS symptoms, and idiopathic MCAS (Table II)