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6.5.3 Oral semaglutide in advanced T2D (mean disease duration: 1415 years) In patients with long-standing T2D and moderate renal impairment (estimated glomerular filtration rate 3059 mL/min/1.73 m 2 ) (PIONEER 5), oral semaglutide 14 mg was significantly more effective than placebo in reducing HbA 1c (ETD: 0.8%

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Lau KTK, Wong CKH, Au ICH et al (2022) Switching to versus addition of incretin-based drugs among patients with type 2 diabetes taking sodium-glucose cotransporter-2 inhibitors