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11 Conclusion and future perspectives Several studies have indicated that an imbalance between oxidative stress and antioxidant defense mechanisms is linked to the onset of ND and MD

Palmitoylation alters LDHA activity and pancreatic cancer response to chemotherapy

We deem ferroptosis-associated cell death a pivotal new field of scientific study in ocular diseases and consider it a new therapeutic target in the treatment of some eye disorders

Chronic sleep deprivation or poor sleep quality impairs these restorative processes, potentially reducing glutathione synthesis capacity and increasing oxidative stress through various mechanisms including increased inflammatory signaling, impaired glucose metabolism, disrupted circadian rhythms affecting antioxidant enzyme expression, and increased psychological stress responses

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however, the estimated genetic prevalence of 142 per million is higher than the clinical prevalence of 15 per million reported in other European studies[5]