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Peter de Keizer's pioneering research at Erasmus University Medical Center to its current status as a leading senolytic research tool, FOXO4-DRI demonstrates how precise molecular targeting can enable selective elimination of harmful cellular populations while preserving healthy tissue function

Annals of general psychiatry

This overlap provides a biologically plausible framework through which GLP-1 signaling may help stabilize cellular energy regulation, particularly in the context of metabolic stress, even if direct effects on intrinsic aging processes remain to be fully established

Despite the potential risk, NAION remains relatively uncommon compared to the benefits provided by these medications

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