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98% of the body's reserves are stored there

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This process is mediated by enzymes such as NADP(H) oxidases and xanthine oxidase (Figure 1, reactions a and b) or nonenzymatically by redox-reactive compounds, such as the semi-ubiquinone compound of the mitochondrial electron transport chain (Figure 1, reaction c)

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showed that brain oxidative stress induced by central or peripheral LPS injection is modulated by AT 1 -R, preventing its development by previous CAND or losartan oral administration ( via i.c.v.) induced oxidative stress, which is prevented by central injection of AT 1 -R blockers or angiotensin-converting enzyme inhibitors ( 1 -R, via phospholipase C 1 ( 1 -R may be involved in neurotoxicity effects of others amphetamines derivatives such as 3,4-methylenedioxymethamphetamine