does tirzepatide cause birth defects TLDR on GLP-1 receptor agonists (ozempic, wegovy, monjauro, zepbound etc etc) animal studies suggest a possible association with defects, low fetal weight, and miscarriage but human data (which is limited to Tirzepatide and Pregnancy: Safety Facts

GLP-1RAs may also have effects on a transcriptional level via protein kinase A (PKA), phosphorylating cAMP-response element-binding protein (CREB) in the nuclear membrane to enhance preproinsulin transcription [28]

While this review focused on insulin, the findings apply to GLP-1 medications since both are temperature-sensitive peptide hormones requiring similar storage conditions

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A well-known example is the JAK2 V617F mutation, common in polycythemia vera (PV) and related diseases

Ellie MD does not guarantee similar outcomes for everyone.This post is also just my personal experience and research.

If you go month-to-month, the risk is manageable